Dermocosmetic & Skin Regeneration Support
High-Molecular-Weight Keratin for Biologically Active Dermocosmetic Systems
Kerline HMW keratin is a non-hydrolyzed, high-molecular-weight structural protein engineered for advanced dermocosmetic formulations targeting skin integrity, regeneration, and protection.
Supplied as a ready-to-formulate aqueous solution (1–4%), it enables multifunctional performance in skin care systems.
A Structural Protein Supporting Skin Homeostasis
Unlike low-molecular-weight hydrolyzed proteins, Kerline HMW keratin preserves molecular architecture (main bands 10–60 kDa, SDS-PAGE).
In vitro studies on human keratinocytes (HaCaT) demonstrate:
• Sustained cell proliferation comparable to positive control
• Maintenance of Collagen I expression
• Modulation of α-SMA expression
• Significant reduction of CK18 (marker associated with cellular stress)
These results indicate support of regenerative and homeostatic pathways at cellular level.
Anti-Inflammatory Modulation
In reconstructed skin models and cellular assays, HMW keratin formulations demonstrated:
• Reduction of IL-6 and IL-8 expression
• Improved cellular viability (MTT assay)
• Excellent biocompatibility
This profile suggests potential use in:
• Post-procedure soothing systems
• Barrier-supporting dermocosmetics
• Sensitive skin formulations
• Anti-age structural support systems
(Data derived from internal studies and university collaborations.)
Film-Forming Protective System
HMW keratin forms continuous biomimetic protein films on skin surface.
Functional implications:
• Protective film formation
• Moisture retention support
• Structural reinforcement of stratum corneum surface
• Compatibility with active delivery systems
Unlike synthetic film-formers, keratin is biodegradable and derived from upcycled wool.
Validated in Real Formulations
HMW keratin has been incorporated into:
• Regenerative serum systems
• Lenitive dermocosmetic creams
Demonstrating:
✔ Stability (pH 5–8)
✔ 12-month documented stability
✔ Preservative compatibility
✔ Batch-to-batch reproducibility
Designed for Advanced Dermocosmetic R&D
Compatible with:
• Emulsion systems
• Gel systems
• Hybrid biomaterial matrices
• Active-loaded nanoparticle systems
HMW keratin can function as:
• Film-forming structural protein
• Skin-conditioning active
• Natural carrier for lipophilic actives
From Technical Evaluation to Scalable Supply
Request:
• Technical datasheet
• Stability documentation
• Cellular data summary
• Sample kit (1% or 4% solution)
• Technical call with our R&D team
